Table 1.
Patient demographics and clinical measures.a
| Characteristics patient demographics and clinical measures | All patients (n=83) | Once-daily arm (n=14) | Overnight arm (n=13) | P value | |
| Age (years), mean (SD) | 70.6 (8.1) | 72.2 (2.6) | 70.7 (2.9) | .68 | |
| Gender (Female), n % | 43 (52) | 10 (71) | 6 (46) | .18 | |
| BMI (kg/m2), mean (SD) | 26.7 (5.9) | 25.6 (1.4) | 25.5 (1.9) | .98 | |
| Smoking status, n (%) | .92 | ||||
|
|
Ex-smoker | 64 (77) | 11 (79) | 10 (77) |
|
|
|
Current smoker | 19 (23) | 3 (21) | 3 (23) |
|
| Do you live with someone? n (%) | 43 (52) | 7 (50) | 8 (62) | .55 | |
| FEVb1 L, mean (SD) | 1.2 (0.4) | 1.0 (0.3) | 1.1 (0.5) | .63 | |
| FEV1%, mean (SD) | 52.9 (18.6) | 53.5 (17.7) | 44.8 (18.2) | .52 | |
| FVCc L, mean (SD) | 2.6 (0.8) | 2.3 (0.7) | 2.5 (0.9) | .30 | |
| FVC %, mean (SD) | 83.7 (21.7) | 82.9 (17.7) | 77.8 (15.6) | .52 | |
| FEV1/FVC %, mean (SD) | 51.9 (11.7) | 52.6 (14.5) | 50.8 (10.7) | .72 | |
| MRC Breathlessness Score, mean (SD) | 2.9 (0.8) | 2.6 (0.2) | 2.9 (0.2) | .34 | |
| Number of exacerbation/previous year, median (IQR) | 2 (1-3) | 1.5 (1-2) | 2.0 (1-3) | .43 | |
| Number of hospitalization/previous year, median (IQR) | 0 (0-0) | 0 (0-0) | 0 (0-0) | .37 | |
| Charlson comorbidity index, mean (SD) | 4.1 (1.2) | 4.0 (0.3) | 4.5 (0.2) | .26 | |
aBaseline data reported as mean (SD) or median (IQR) unless stated otherwise. P value is comparison between once-daily and overnight arms. Data analysis was performed using Statistical Package for Social Sciences (SPSS), Version 24.
bFEV1: forced expiratory volume in 1 second.
cFVC: forced vital capacity.