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. 2020 Nov 23;12:693–709. doi: 10.2147/CEOR.S274951

Table 4.

AE Frequencies During BCG Treatment

BCG AE (Number of Studies Reporting AE) Range of Frequency Among Studies (%)
Frequent urination, BCG maintenance (n=4) 17% to 97%
Lower urinary tract symptoms (n=3) 50% to 94%
Pain on urination, BCG maintenance (n=3) 17% to 94%
Hematuria, BCG maintenance (n=4) 15% to 89%
Frequent urination, induction (n=8) 24% to 83%
Pain on urination, induction (n=10) 9% to 83%
Nocturia (n=2) 38% to 80%
Hematuria (n=15) 6% to 72%
Cystitis (n=5) 5% to 58%
Urgency (n=4) 1% to 56%
Urinary retention (n=3) 1% to 56%
Difficult urination (n=3) 5% to 52%

Note: Data from these studies.11,20,27,46–61

Abbreviations: AE, adverse event; BCG, Bacillus Calmette-Guerin; NMIBC, non-muscle invasive bladder cancer.