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. 2021 Jan;1866(1):158815. doi: 10.1016/j.bbalip.2020.158815

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Crown Copyright © 2020 Published by Elsevier B.V.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 2 — Comparative analysis of sphingoid bases, dhCer, Cer and αOH-Cer species in clinical isolates of C. auris: (a) 7 sphingoid bases were detected among which DHS showed significant differences among the three sets of isolates. (b) DhCer are abundant in C. auris. 13 species of dhCer were detected which were differentiated on the basis of fatty acid chain length. dhCer with fatty acyl chain length of 12:0 and 20:1 was displayed significant changes among the tested isolates. (c) Cer and αOH-Cer were detected in C. auris. 11 species among these show significant changes. The unusual sphingoid backbone d19:2 was detected in all isolates and particularly showed enrichment in AmB^R. Data for all the replicates are shown in the colored diagram. Red boxed SL species distribution and its significances are highlighted in the right panels (distribution plots). The distribution plots were plotted using the individual value of each sample within the group and compared with the other groups. The data can be found in Supplementary File 1. ‘*’ and ‘**’ represent p-values <0.05 and 0.01, respectively. ‘ns’ stands for no significant change.

Comparative analysis of sphingoid bases, dhCer, Cer and αOH-Cer species in clinical isolates of C. auris: (a) 7 sphingoid bases were detected among which DHS showed significant differences among the three sets of isolates. (b) DhCer are abundant in C. auris. 13 species of dhCer were detected which were differentiated on the basis of fatty acid chain length. dhCer with fatty acyl chain length of 12:0 and 20:1 was displayed significant changes among the tested isolates. (c) Cer and αOH-Cer were detected in C. auris. 11 species among these show significant changes. The unusual sphingoid backbone d19:2 was detected in all isolates and particularly showed enrichment in AmB^R. Data for all the replicates are shown in the colored diagram. Red boxed SL species distribution and its significances are highlighted in the right panels (distribution plots). The distribution plots were plotted using the individual value of each sample within the group and compared with the other groups. The data can be found in Supplementary File 1. ‘*’ and ‘**’ represent p-values <0.05 and 0.01, respectively. ‘ns’ stands for no significant change.