Fig. 5.

Memantine treatment rescues impaired spatial memory performance in Tg4-42^hom mice. a, b All groups showed progressively reduced escape latencies during the cued and acquisition training. c While Tg4-42^hom showed no preference for any of the quadrants during the probe trial, WT controls, memantine-treated WT, and memantine-treated Tg4-42^hom mice spent significantly more time in the target quadrant (T) compared with all the other quadrants (RLO), disclosing intact spatial reference memory. d–f No differences in swimming speed were observed within all the groups in cued training, acquisition training, and probe trial. a–e Two-way repeated measures ANOVA followed by Bonferroni multiple comparisons. f One-way ANOVA followed by Bonferroni’s multiple comparisons test. *p < 0.05, ***p < 0.001. All data were given as mean ± SEM (T, target; L, left; R, right; O, opposite)