Fig. 7.

Chronic oral memantine treatment ameliorates impaired neurogenesis in the DG of Tg4-42^hom mice. Analysis of doublecortin (DCX)-stained sections revealed a significantly reduced number of DCX-positive cells in Tg4-42^hom mice compared with untreated WT mice (a, b). While chronic memantine treatment did not alter the number of new-born cells in WT mice, a significantly increased number was detected in memantine-treated Tg4-42 mice. One-way ANOVA followed by Bonferroni’s multiple comparisons test. *p < 0.05, ***p < 0.001, scale bar: 50 μm