Fig. 2. Reorganization of the local chromatin neighbourhood at the IL1 locus.

a, b Hi-C matrices (10 kb resolution) of the IL1 locus corresponding to growing and RIS IMR90 cells (a) and control and TNFα-treated IMR90 cells from Jin et al.¹⁵ (b). c Differential capture Hi-C matrix at the IL1 locus (log-fold change of RIS/growing interactions estimated genome-wide using all replicates) at HindIII resolution, with annotated growing IMR90 loops (from Rao et al.¹³) and inferred new loop formation in RIS cells. d Differential Hi-C matrix at the IL1 locus (log-fold change TNFα) at 10 kb resolution. e, f Significant differential enhancer-promoter contacts between promoters of differentially expressed genes at the IL1 locus and associated enhancers, aligned with (c) and (d), respectively. .