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. 2020 Nov 27;11:6078. doi: 10.1038/s41467-020-19967-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Histopathologic findings showing infiltration of lymphocytes in the lung of AGM (NC40 and NC34) and RM (FR04 and GH99) with mild (NC40 and FR04), moderate (GH99), and severe disease (NC34). b Frequency of NKG2a⁺ cells in the blood or c BAL of 4 AGM and 4 RM at baseline, 2 weeks and 3 weeks post SARS-CoV-2 infection by flow cytometry. d Representative flow cytometry plot showing a decreased frequency of NGK2a⁺ cells in PBMCs and increased frequency in BAL to baseline in at week 3 post-SARS-CoV-2 infection respect to baseline. One animal for each species is shown. e Decrease in the frequency of CXCR3⁺ NKG2a⁺ cells in the blood at 2 weeks and 3 weeks post SARS-CoV-2 infection compared to the baseline. f Absolute number of lymphocytes before and after infection. g tSNE plots displaying kinetics of PD-1 expression (in red) on lymphocytic cell populations over time. h Frequency of PD-1⁺ Th2 (CXCR3⁻ CCR6⁻) CD4⁺ T cells is increased in RM and i in AGM overtime following the infection. j Changes in the percentage of Th2 (purple), Th1 (blue) and Th17 (gray) cells within the total PD-1⁺ CD4⁺ T cell population. k Significant increase in the percentage of PD-1⁺ CD8⁺ T cells in BAL. Analysis of variance (ANOVA) was used for comparing statistical differences between multiple groups, followed by Dunn’s multiple comparison tests for b, c, and k.