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. 2020 Nov 27;3:724. doi: 10.1038/s42003-020-01434-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Molecular interaction network affected by aberrant (P)RR expression in HPDE-1/E6E7 cell population. Red shapes: upregulated molecules; Green shapes: downregulated molecules. Straight line: direct interaction. Dotted line: indirect interaction. The components of the imitation switch (ISWI) chromatin remodelling complex are dominant in this network. b The components of several chromatin remodelling complexes affected by aberrant (P)RR expression. Underline: molecules interacting with SMARCA5. Red arrows: upregulated molecules; blue arrows: downregulated molecules. c Upper: Volcano plot of SMARCA5. Arrows show the significant upregulation of SMARCA5 under (P)RR overexpression in HPDE-1/E6E7 cells. Lower: Representative image showing the upregulation of SMARCA5 with western blot. d Representative image for the expression of components of DNA replication, DNA repair and telomere maintenance machinery in HPDE-1/E6E7 cells with SMARCA5 overexpression. e Binding of CTF of (P)RR with SMARCA5 under coimmunoprecipitation using insoluble nucleus. MWM Molecular Weight Marker; Lys Lysates; rIgG rabbit IgG; IP Immunoprecipitation; IB Immunoblot. f Expression of molecules responsible for genomic stability in (P)RR-expressing HPDE-1/E6E7 cells transfected with two different SMARCA5 siRNAs. Consistent results are obtained in three independent experiments for western blot and coimmunoprecipitation.