Table 1.

Optimization and physicochemical characterization of SM-PLGA nanosuspension

S. No.	Polymer Weight	SM Amount (mg)	PVA (%)	Sonication Amplitude (W)	Sonication Time (Minutes)	Particle Size (nm)	PDI	ZP (-mV)	EE (%)
1	100	100	0.5	40	2.5	208.00±13.20	0.126±0.048	12.90±0.750	65.49±2.619
2	200	100	0.5	40	2.5	238.80±6.38	0.117±0.021	13.43±0.030	75.87±0.260
3	100	100	1	40	2.5	244.00±19.81	0.165±0.043	10.24±0.194	67.56±0.151
4	200	100	1	40	2.5	255.30±20.23	0.167±0.046	10.53±0.850	76.40±0.570
5	100	100	0.5	80	5	233.13±21.55	0.118±0.053	11.36±0.233	66.99±1.090
6	200	100	0.5	80	5	298.60±13.81	0.248±0.007	12.93±0.266	77.03±0.990
7	100	100	1	80	5	226.13±11.46	0.162±0.040	10.02±0.288	77.12±1.120
8	200	100	1	80	5	247.00±3.64	0.196±0.052	11.67±0.670	79.17±0.870

Note: Data represented as Mean ± SEM, n=3.

Abbreviations: SM, sesamol; PVA, polyvinyl alcohol; PDI, polydispersity index; ZP, zeta potential; EE, entrapment efficiency.