Table 2.
Pharmacokinetic parameters of standard and formulation group
| Parameter | Standard Drug | SM-PLGA Nanosuspension |
|---|---|---|
| Ke (h-1) | 0.367 ± 0.082 | 0.050 ± 0.002 |
| T1/2 (h) | 2.097 ± 0.483 | 13.947 ± 0.596 |
| Tmax (h) | 0.250 ± 0.500 | 60.000 ± 2.250 |
| Cmax (µg/mL) | 65.056 ± 8.434 | 1153.780 ± 14.550 |
| AUC0-t (µg.h/mL) | 24679.000 ± 3104.000 | 28649.298 ±1440.093 |
| MRT (h) | 0.849 ± 0.054 | 62.007 ± 0.347 |
| Vd (L) | 1.300 ±0.380 | 6.430 ± 0.132 |
Note: Data represented as mean ± SEM, n=3.
Abbreviations: Cmax, peak plasma concentration; Tmax, time to achieve peak plasma concentration; Ke, elimination rate constant; Vd, volume of distribution; AUC0-t, area under the curve from the time of administration to time “t”; MRT, mean residence time.