Table 3.

Effect of SM-PLGA on histopathological parameters

	S. No.	Histopathology Parameter	Day 5	Day 10	Day 15
NC	1	Epidermal Regeneration	++	+++	+++
	2	Granulation tissue	+++	+++	+++
	3	Inflammatory cell infiltration	++	+	+
	4	Angiogenesis	+++	++	+++
	5	Proliferation of fibroblast cells	+++	+++	+++
	6	Collagen deposit	++	++	+++
DFU	1	Epidermal Regeneration	+	++	++
	2	Granulation tissue	+	++	++
	3	Inflammatory cell infiltration	++	++	+
	4	Angiogenesis	+	+	+
	5	Proliferation of fibroblast cells	++	++	++
	6	Collagen deposit	+	+	+
SM50	1	Epidermal Regeneration	+	+	+++
	2	Granulation tissue	+++	++	+++
	3	Inflammatory cell infiltration	+++	+++	+
	4	Angiogenesis	++	++	++
	5	Proliferation of fibroblast cells	++	++	++
	6	Collagen deposit	+	+	++
SM100	1	Epidermal Regeneration	++	++	+++
	2	Granulation tissue	+	+++	+++
	3	Inflammatory cell infiltration	+	+	+
	4	Angiogenesis	+	++	++
	5	Proliferation of fibroblast cells	++	++	++
	6	Collagen deposit	+++	++	++
SM-PLGA	1	Epidermal Regeneration	++	+++	+++
	2	Granulation tissue	++	+++	+++
	3	Inflammatory cell infiltration	+++	+	+
	4	Angiogenesis	++	+++	+++
	5	Proliferation of fibroblast cells	++	++	++
	6	Collagen deposit	++	+++	+++

Note: Scoring of histology, + Mild, ++ Moderate, +++ Extensive.