Table 1.
The similarities and uniqueness of 17 anti-breast cancer drugs and usnic acid according to miRNAs
| Drug name | Responsible miRNA numbers | Only their unique number miRNA | Number of miRNAs found in any other drugs | Uniqueness ratio (%) | Similarity ratio (%) |
|---|---|---|---|---|---|
| Usnic acid MDA-MB-231 | 66 | 42 | 24 | 63.63 | 36.36 |
| Usnic acid BT-474 | 16 | 8 | 8 | 50 | 50 |
| Usnic acid MCF-7 | 8 | 7 | 1 | 87.50 | 12.50 |
| Tamoxifen | 10 | 1 | 9 | 10 | 90 |
| Gemcitabine | 56 | 13 | 43 | 23.20 | 76.70 |
| Metformin | 10 | – | 10 | 0 | 100 |
| Curcumin | 62 | 13 | 49 | 20.96 | 79.03 |
| Sulindac Sulfide | 131 | 53 | 78 | 40.45 | 59.54 |
| Doxorubicin | 39 | 6 | 33 | 15.38 | 84.61 |
| Vincristine | 1 | 1 | – | 100 | 0 |
| Cisplatin | 56 | 19 | 37 | 33.92 | 66.07 |
| Fulvestrant | 4 | – | 4 | 0 | 100 |
| Bicalutamide | 37 | 12 | 25 | 32.43 | 67.56 |
| 5-Fluorouracil | 208 | 125 | 83 | 60.09 | 39.90 |
| Paclitaxel | 16 | 1 | 15 | 6.25 | 93.75 |
| Letrozole | 1 | – | 1 | 0 | 100 |
| Docetaxel | 20 | 2 | 18 | 10 | 90 |
| Topotecan | 12 | 5 | 7 | 41.66 | 58.33 |
| Mitoxantrone | 2 | – | 2 | 0 | 100 |
| Capecitabine | 2 | – | 2 | 0 | 100 |