Why carry out this study?

Limited evidence is currently available on the impact of concomitant use of methotrexate (MTX) on the efficacy and safety of biologic disease-modifying anti-rheumatic drugs (bDMARDs) approved for the treatment of patients with psoriatic arthritis (PsA).

The aim of this study was to investigate the efficacy and safety of two bDMARDs, ixekizumab and adalimumab, with or without MTX through week 52 in patients with PsA.

What was learned from the study?

The results of this study suggest that ixekizumab demonstrated identical efficacy in joint endpoints with or without concomitant MTX, while adalimumab efficacy appears to increase with the concomitant use of MTX.

The safety of both agents was consistent with their known safety profiles regardless of concomitant MTX use.

The results of this study inform evidence-based treatment decisions when considering concomitant MTX use when prescribing ixekizumab or adalimumab for patients with PsA.