Table 2.
Validation of multivariable logistic regression models for insufficient response to MTX (DAS28 > 3.2) at 3 months of treatment in an external validation cohort (U-Act-Early)
| tREACH derivation cohort N = 173 |
U-Act-Early validation cohort N = 91 |
|
|---|---|---|
| Predictors | OR (95% CI) | OR (95% CI) |
| DAS28 > 5.1 | 3.7 (1.62–8.38)** | 4.1 (1.44–11.82)** |
| HAQ > 0.6 | 2.8 (1.15–7.00)* | 2.1 (0.67–6.35) |
| ABCB1 GG/GA | 2.4 (1.06–5.23)* | 1.0 (0.37–2.75) |
| ABCC3 TC/CC | 3.1 (1.39–6.94)** | 0.6 (0.23–1.79) |
| Folate < 750 nmol/l | 2.1 (0.97–4.40) | 3.4 (0.88–12.79) |
| Smoker | 4.2 (1.91–9.42)** | 1.3 (0.44–4.00) |
| BMI > 25 kg/m2 | 3.3 (1.52–7.21)** | 1.6 (0.62–4.23) |
| AUC (95% CI) | 0.81 (0.74–0.87) | 0.75 (0.64–0.85) |
The left column presents data from the derivation cohort (tREACH) and the right of the external validation cohort (U-Act-Early). OR odds ratio, CI confidence interval. Predictors that contributed significantly to the model are indicated with an asterisk, where *P < 0.05 and **P < 0.01