FIGURE 2.

Impact of PomJ and PL drink on gut microbiota. Microbial genera identified to be significantly different in abundance between baseline and final in (A) PL (n = 8) and (B) PomJ (n = 11) by DESeq2 (40) (P < 0.05; *adjusted P < 0.2). In DESeq2, negative and positive log₂-fold change value denotes decreased or increased abundance at final compared with baseline, respectively. (C) Genera identified to be significantly different in abundance by DESeq2 between PomJ and PL, including baseline and final (P < 0.05). (D) Changes from final and baseline visits in circulating Trp microbial metabolite IS, IPA, and IAA are associated with changes in gut microbiota composition. Heatmap depicting the Spearman correlation patterns (*P < 0.05, **P < 0.01) of changes in relative abundance of gut bacterial genera and concentrations of blood Trp microbial metabolites. IAA, indole acetate; IPA, indole propionate; IS, indole sulfate; PL, placebo; PomJ, pomegranate juice.