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. 2020 Nov 25;4(11):nzaa165. doi: 10.1093/cdn/nzaa165

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© The Author(s) 2020. Published by Oxford University Press on behalf of the American Society for Nutrition.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of dietary EA and UA supplementation on gut microbiota. α-Diversity indexes (A) Chao1 and (B) Shannon in experimental mice fed for 8 wk with HFHS diet or HFHS diets supplemented with EA or UA. Data are presented as means ± SEMs (HFHS, n = 8; HFHS/EA, n = 6; HFHS/UA, n = 6). Labeled means without a common letter differ, P < 0.05. (C) Principal coordinate analysis plot of β-diversity measure Bray–Curtis dissimilarity. Differential abundance analyses at genus level were performed between (D) EA vs. HFHS, (E) UA vs. HFHS, and (F) UA vs. EA (P < 0.05, *adjusted P < 0.2). Data plotted as log₂-fold change. EA, ellagic acid; HFHS, high-fat/high-sucrose; UA, urolithin A.