Table 3.
List of the top 30 most downregulated genes in H. pylori G27 biofilm conditions compared to cells in planktonic conditions (cutoff ratio ≥ 1 log2 fold-change and P-value < 0.05) using RNA-seq analysis, grouped by functional role categories. These genes are all expressed to lower levels in the biofilm cells.
| Name | Product | Fold-change |
|---|---|---|
| HPG27_256 | Ferredoxin | −4.39 |
| HPG27_516 | Hypothetical protein | −3.01 |
| HPG27_1015 | Zinc-metalloprotease | −2.86 |
| HPG27_1271 | Hypothetical protein | −2.84 |
| HPG27_1035 | Pseudo uridylate synthase I | −2.71 |
| HPG27_1180 | Hypothetical protein | −2.62 |
| HPG27_1008 | SodB, iron-dependent superoxide dismutase | −2.61 |
| HPG27_591 | Mda66, modulator of drug activity | −2.60 |
| HPG27_527 | Hypothetical protein | −2.57 |
| HPG27_937 | Hypothetical protein | −2.56 |
| HPG27_338 | KgtP, alpha-ketoglutarate permease | −2.47 |
| HPG27_1314 | Type III restriction enzyme M protein | −2.45 |
| HPG27_277 | AibA, AI-2 periplasmic binding protein | −2.41 |
| HPG27_1376 | Hypothetical protein | −2.39 |
| HPG27_1044 | Glk, glucokinase | −2.36 |
| HPG27_548 | OorD, 2-oxoglutarate oxidoreductase subunit | −2.36 |
| HPG27_1205 | NADH-ubiquinone oxidoreductase chain A | −2.35 |
| HPG27_783 | TrxA, thioredoxin | −2.33 |
| HPG27_1125 | Hypothetical protein | −2.32 |
| HPG27_957 | Cyclopropane fatty acid synthase | −2.31 |
| HPG27_1329 | Biotin synthetase | −2.31 |
| HPG27_887 | Hypothetical protein | −2.31 |
| HPG27_521 | Ribosomal protein S21 | −2.29 |
| HPG27_1156 | Hypothetical protein | −2.25 |
| HPG27_1206 | NuoB, NADH oxidoreductase I | −2.25 |
| HPG27_1273 | FumC, fumarase | −2.22 |
| HPG27_469 | Urease-enhancing factor | −2.21 |
| HPG27_549 | OorA, 2-oxoglutarate oxidoreductase subunit | −2.19 |
| HPG27_279 | DppC, dipeptide transport system permease protein | −2.14 |
| HPG27_1007 | Adhesin-thiol peroxidase | −2.14 |
| HPG27_306 | FlgH, flagellar L-ring protein precursor | −2.14 |