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. 2020 Nov 27;11(11):1016. doi: 10.1038/s41419-020-03222-1

Fig. 2. HMPL-013 causes no intraocular toxicity.

Fig. 2

The mice were randomly divided into four groups:normal, CNV 7 d, CNV 7 d + DMSO, and CNV 7 d + HMPL-013. a HE staining on retina–RPE–choroid complex paraffin section was performed. b Quantification of the ratio of A to B was shown. c DAPI (blue) and TUNEL (green) stain on retina–RPE–choroid complex cryosections was performed. d The TUNEL fluorescent intensity was analyzed. e Representative scotopic ERG tracings at the light intensity of −1.02 log cds/m2. Amplitudes of f a-waves and g b-waves from normal, CNV 7 d, CNV 7 d + DMSO, and CNV 7 d + HMPL-013 groups. n = 3 in each group.