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. 2020 Nov 27;11(11):1016. doi: 10.1038/s41419-020-03222-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The mice were randomly divided into four groups: normal, CNV 7 d, CNV 7 d + DMSO, and CNV 7 d + HMPL-013. a Immunostaining of NOS2 (M1-type macrophage marker, red), IB4 (green), and DAPI (blue) on choroidal flat mounts. b Immunostaining of Arg1 (M2-type macrophage marker, red), IB4 (green), and DAPI (blue) on choroidal flat mounts. c The immunofluorescence of DAPI (blue), F4/80 (red), and IB4 (green) was shown. ELISA was done to detect pro-inflammatory cytokines, including IL-6 (d), TNF-α (e), and RANTES (f) in retina–RPE–choroid complex tissues. ^***P < 0.005 vs. normal group; ^###P < 0.005, ^##P < 0.01 vs. CNV 7 d group in c–e. n = 10 in each group.