Table 2.
Association between IL-6 levels, clinical, anthropometrical, and biochemical determinants.
| Group 1 IL − 6 > 100 pg/ml, N = 55 | Group 2 IL-6 10-100 pg/ml, N = 55 | Group 3 IL − 6 < 10 pg/ml, N = 55 | Chi2/ANOVA | p | |
|---|---|---|---|---|---|
| Hypertension | 26 (42.3) | 25 (45.4) | 15 (27.3) | 5.61 | 0.06 |
| Dyslipidemia | 23 (41.8) | 15 (27.3) | 15 (27.3) | 3.55 | 0.17 |
| Diabetes mellitus | 15 (27.3) | 11 (20.0) | 7 (12.7) | 3.64 | 0.16 |
| Charlson Comorbidity Index Score | 1.33 (1.66) | 0.55 (1.02) | 0.64(1.38) | 12.68 | 0.006 |
| ALT (U/l) | 47.1 (20.1) | 40.8 (22.9) | 49.2 (43.0) | 57.39 | 0.01 |
| AST (U/l) | 32.0 (15.0) | 53.9 (22.8) | 52.3 (43.2) | 37.93 | 0.48 |
| GGT (U/l) | 71.4 (76.7) | 109.9 (121.1) | 79.2 (79.7) | 15.42 | 0.08 |
| LDH (U/l) | 350.1 (117.6) | 388.5 (149.0) | 335.3 (157.0) | 4.17 | 0.14 |
| CRP (mg/dl) | 182.1 (217.8) | 127.9 (70.7) | 88.2 (72.2) | 90.67 | 0.02 |
| Leucocytes (counts/μl) | 7763 (4026) | 7849.4 (3075) | 7304 (3553) | 3.76 | 0.69 |
| NLI | 10.9 (10.6) | 7.2 (5.4) | 5.6 (5.3) | 34.56 | 0.001 |
| RDW (%) | 13.6 (1.3) | 13.2 (1.2) | 13.0 (0.9) | 5.96 | 0.02 |
| D-Dimer (μg/ml) | 1.60 (2.11) | 2.40 (9.01) | 1.05 (0.96) | 205.80 | 0.44 |
| Ferritin (ng/ml) | 1283(953) | 1096 (874) | 806 (877) | 0.41 | 0.05 |
| Total cholesterol (mg/dl) | 135.3 (33.2) | 139.5 (25.2) | 145.6 (36.6) | 7.60 | 0.20 |
| SBP (mmHg) | 139.2 (24.2) | 138.1(21.3) | 136.2 (20.3) | 1.82 | 0.78 |
| DBP (mmHg) | 78.6 (14.4) | 79.4 (12.8) | 79.2 (15.3) | 1.73 | 0.94 |
| Baseline blood glucose (mg/dl) | 148.1 (77.0) | 118.9(44.3) | 120.9 (41.2) | 24.49 | 0.01 |
| BMI (kg/m2) | 28.8 (4.5) | 29.0 (5.0) | 27.2 (3.9) | 2.60 | 0.09 |
| Current smoker | 7 (12.7) | 3 (5.4) | 1 (1.8) | 5.91 | 0.05 |
| Drink standard units | 8.76 (39.94) | 1.74 (4.40) | 0.78 (2.47) | 1.87 | 0.15 |
| NLI 2019 | 2.0 (3.5) | 2.8 (4.2) | 1.7 (0.8) | 59.75 | 0.28 |
| Hospital stay days | 22.0 (17.1) | 11.9 (10.4) | 8.6 (5.8) | 18.04 | <0.001 |
| ICU admission | 16 (29.1) | 4 (7.2) | 2 (3.6) | 18.04 | <0.001 |
| Mortality | 13 (23.6) | 3 (5.4) | 0 (0.0) | 20.67 | <0.001 |
ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: Gamma Glutamyl Transpeptidase; LDH: lactate dehydrogenase; CRP: C-reactive Protein; NLI: Neutrophil/Lymphocyte index; RDW: Red Cell Distribution Width; SBP: Systolic Blood Pressure; DBP: Diastolic Blood Pressure; BMI: Body Mass Index. ∗Qualitative variables are expressed in number and proportion. Quantitative variables are expressed in mean and standard deviation.