Table 1.

Significant conserved RNA structural motifs with potential functional roles in IAV segment interactions and genome assembly, as supported by experimental evidence.

vRNA Segment	Nucleotide Region		Predicted Structure	Publication
	(+) Sense Numbering	(−) Sense Numbering
1	1823–1944	398–519	motif with long helical regions and two hairpins	[41]
2	289–309	2033–2053	hairpin	[19]
	497–561	1781–1845	hairpin	[41]
5	16–39	1527–1550	hairpin	[9,25,33]
	22–68	1498–1544	two hairpins	[41]
	70–82	1484–1496	hairpin	[9,19,25]
	89–105	1461–1477	hairpin	[33]
	191–203	1363–1375	hairpin	[9,25]
	580–590	976–986	hairpin	[9,25,33]
	922–938	628–644	hairpin	[33]
	1090–1106	460–476	hairpin	[9,25]
	1144–1160	406–422	hairpin	[9,25]
	1431–1479	87–135	hairpin/pseudoknot	[9,19,25,33,41,42]
	1476–1530	36–90	hairpin	[33]
7	21–63	965–1007	dynamic	[16,26]
	219–240	788–809	hairpin	[9,26,39]
	249–260	768–779	hairpin	[9,26]
	318–333	695–710	hairpin	[9,26]
	443–450	578–585	hairpin	[9,26]
	671–691	337–357	hairpin	[9,26]
	857–890	138–171	hairpin	[9,26]
	967–994	34–61	hairpin	[9,16,26,34,36,39,43,44]
8	22–86	790–854	hairpin	[41]
	96–101/175–180	696–701/775–780	helix	[24,38]
	109–118/163–172	704–713/758–767	helix	[24,38]
	128–140	736–748	hairpin	[24,38]
	257–277	599–619	hairpin	[19]
	529–534/578–583	293–298/342–347	helix	[9,24]
	549–564	312–327	hairpin	[9,24]
	588–615	261–288	hairpin	[9,24]