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AXL receptor and GAS6 protein structures. (A) AXL is structurally composed by two immunoglobulin (Ig)-like domains, two fibronectin type III (FNIII) repeats, a transmembrane region and cytoplasmatic domain, implicated in kinase activity. (B) GAS6 is characterized by a γ-carboxyglutamic acid (Gla) domain, a loop region, four EGF-like repeats and two C-terminal globular laminin G-like (LG) domains that promote interaction with AXL.
