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. 2020 Nov 12;12(11):3476. doi: 10.3390/nu12113476

Figure 1.

Figure 1

Transcription feedback loops driving circadian rhythm. CLOCK and BMAL1 heterodimers initiate expression of PERs, CRYs, REV–ERBα, and RORs by binding to the E–box element. PER and CRY heterodimers inactivate CLOCK and BMAL1. REV–ERBα and RORs activate or inhibit, respectively, the expression of ROR response element (RORE) containing genes including Cry and Bmal1. Abbreviations: BMAL1—brain and muscle ARNT–like protein 1; CLOCK—circadian locomotor output cycles kaput; CRY—cryptochrome; PER—period, ROR—retinoic acid–related orphan receptor.