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. 2020 Nov 11;21(22):8467. doi: 10.3390/ijms21228467

Figure 1.

Figure 1

Suppression of FASN is highly detrimental for the growth of c-Myc HCC3-4 and HCC4-4 derived mouse HCC cell lines. (A) Western blot analysis of HCC3-4 and HCC4-4 cells subjected to scramble or FASN-specific siRNA (si-Fasn). (B) Quantitative real-time RT-PCR showing effective downregulation of Fasn following siRNA-mediated siRNA. (C) Quantitative real-time RT-PCR showing that FASN knockdown does not affect c-Myc mRNA levels in the two cell lines. (D) Effect of Fasn silencing on the proliferation rate of HCC3-4 and HCC4-4 cell lines. (E) Effect of Fasn silencing on the apoptosis degree of HCC3-4 and HCC4-4 cell lines. Tukey–Kramer test: at least p < 0.01; a, vs. scramble or scramble 24 h; b, vs. si-Fasn 24 h; c, vs. scramble 48 h.