Table 2.
Marginal means of health-related quality of life scores according to the tumor characteristics.
| Tumor Characteristics | Tumor Characteristics | PCS-12 | MCS-12 | FBSI | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Category | N | Mean (95% CI) | p-Value | N | Mean (95% CI) | p-Value | N | Mean (95% CI) | p-Value | |
| Tumor size | T0 | 619 | 47.19 (37.97, 56.41) | 0.77 | 619 | 48.22 (39.15, 57.29) | 0.10 | 640 | 23.09 (18.25, 27.93) | 0.40 |
| T1 * | - | 44.73 (43.60, 45.85) | - | - | 48.75 (47.64, 49.85) | - | - | 23.77 (23.19, 24.36) | - | |
| T2 | - | 46.27 (44.26, 48.28) | - | - | 50.39 (48.41, 52.37) | - | - | 25.03 (24.00, 26.07) | - | |
| T3 | - | 44.43 (39.65, 49.21) | - | - | 47.06 (42.36, 51.77) | - | - | 23.65 (21.14, 26.16) | - | |
| T4 | - | 45.60 (37.08, 54.11) | - | 39.72 (31.35, 48.10) | - | - | 23.64 (19.47, 27.80) | - | ||
| Node infiltration | N0 | 632 | 45.80 (44.46, 47.15) | 0.65 | 632 | 49.14 (47.81, 50.46) | 0.99 | 652 | 24.36 (23.68, 25.04) | 0.81 |
| N1 * | - | 45.05 (43.24, 46.85) | - | - | 49.15 (47.38, 50.93) | - | - | 23.97 (23.04, 24.90) | - | |
| N2 | - | 41.06 (34.05, 48.07) | - | - | 48.54 (41.65, 55.44) | - | - | 22.79 (19.27, 26.31) | - | |
| N3 | - | 41.31 (32.92, 49.70) | - | - | 49.51 (41.25, 57.77) | - | - | 22.64 (18.35, 26.93) | - | |
| Complete clinical remission | No * | 628 | 45.14 (39.52, 50.76) | 0.99 | 628 | 50.03 (44.47, 55.60) | 0.69 | 649 | 24.31 (21.46, 27.16) | 0.85 |
| Yes | - | 45.13 (44.31, 45.95) | - | - | 48.89 (48.08, 49.70) | - | - | 24.06 (23.63, 24.48) | - | |
| Recurrence | No * | 611 | 45.38 (44.55, 46.21) | 0.01 | 611 | 48.76 (47.94, 49.58) | 0.17 | 631 | 24.16 (23.73, 24.59) | 0.12 |
| Yes | - | 39.92 (35.65, 44.18) | - | - | 51.78 (47.58, 55.98) | - | - | 22.43 (20.28, 24.59) | - | |
| Pathological TNM stage | I * | 642 | 45.53 (44.41, 46.64) | 0.30 | 642 | 48.44 (47.34, 49.54) | 0.40 | 663 | 24.12 (23.54, 24.70) | 0.45 |
| II | - | 44.88 (43.56, 46.20) | - | 49.91 (48.60, 51.21) | - | - | 24.26 (23.58, 24.94) | - | ||
| III | - | 44.90 (42.42, 47.38) | - | - | 49.07 (46.62, 51.52) | - | - | 23.57 (22.28, 24.87) | - | |
| IV | - | 34.61 (22.88, 46.34) | - | - | 46.64 (35.04, 58.23) | - | - | 19.90 (13.72, 26.08) | - | |
| Histological grade | Well differentiated * | 642 | 45.10 (43.64, 46.56) | 0.86 | 642 | 50.76 (49.32, 52.20) | 0.001 | 663 | 24.82 (24.07, 25.57) | 0.07 |
| Moderately differentiated | - | 45.42 (44.15, 46.68) | - | - | 47.32 (46.08, 48.57) | - | - | 23.83 (23.17, 24.48) | - | |
| Poorly differentiated | - | 44.88 (43.34, 46.41) | - | - | 49.63 (48.12, 51.15) | - | - | 23.65 (22.85, 24.46) | - | |
| Intrinsic subtype | Luminal A * | 634 | 44.98 (43.97, 45.99) | 0.72 | 634 | 49.03 (48.04, 50.03) | 0.90 | 655 | 23.98 (23.46, 24.50) | 0.27 |
| Luminal B | - | 45.67 (43.73, 47.60) | - | - | 50.03 (48.12, 51.94) | - | - | 24.30 (23.30, 25.31) | - | |
| Her2 | - | 46.08 (42.15, 50.02) | - | - | 48.37 (44.49, 52.25) | - | - | 25.16 (23.10, 27.22) | - | |
| Basal-like | - | 44.66 (41.35, 47.97) | - | - | 48.04 (44.78, 51.31) | - | - | 23.16 (21.41, 24.92) | - | |
| Luminal ONI ** | - | 48.07 (43.77, 52.38) | - | - | 48.63 (44.39, 52.88) | - | - | 26.27 (24.07, 28.48) | - | |
| Non-luminal ONI ** | - | 41.97 (31.61, 52.32) | - | 49.62 (39.41, 59.83) | - | - | 23.86 (18.45, 29.28) | - | ||
These data are adjusted for age at diagnosis, educational level, province of recruitment, stage at diagnosis, and histological grade at diagnosis. Results on metastasis have been omitted because of lack of convergence. In tumor size, this category is not shown due to convergence problems. N refers to the number of women included in each analysis. The drop-off in numbers is due to the lack of adjusting variables. * Categories used as reference in the analysis; ** ONI: otherwise not identified.