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Mechanisms mediating the effect of PXR activation on hepatic glucose uptake. In the postprandial state, GLUT2 glucose transporter facilitates glucose uptake into the hepatocytes. In the next step of glucose utilization, glucose is phosphorylated by GCK. Ligand-activated PXR represses expression of both GLUT2 and GCK. PXR activation also relocates GLUT2 from the plasma membrane to the cytosol. Together, these alterations reduce postprandial hepatic glucose uptake.
