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. 2020 Nov 10;21(22):8445. doi: 10.3390/ijms21228445

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sepsis EVs (S-EVs) enrich 12 chosen miRNAs expected to target TNF-α and IL-17A. (A) Among sepsis-augmented miRNAs in S-EVs, 12 miRNAs shown in Venn diagram were selected to further analyze their expressions. (B) RT-qPCR analysis for miRNA expressions in the EVs. These miRNAs were tested for their increased enrichment in S-EV. As a control, U6 was used to normalize miRNA levels. Total RNAs were isolated from EVs pooled from 5 mice in each group. At least four separate experiments were performed. Results are shown as the mean ± SEM. S-EV, sepsis EVs; and C-EV, control EVs. * p < 0.05; *** p < 0.001; **** p < 0.0001; and ns, not significant.