Table 3.
In vitro thymidylate synthase (TS) activity of the active compounds 12 and 13, as well as PTX.
| Compounds | IC50 (µM) |
|---|---|
| 12 | 2.52 |
| 13 | 4.38 |
| PTX | 6.75 |
IC50 values are the mean ± SD of three separate experiments. PTX: pemetrexed.
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