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Structure of a chimeric antigen receptor (CAR)—a cell-surface receptor comprising an extracellular ligand binding domain (which recognizes a specific tumor-associated antigen (TAA)), a transmembrane (TM) domain, and an intracellular signaling domain. The latter consists of a T cell activation domain and one or more co-stimulatory domains (CD27, CD28, ICOS, 4-1BB, and/or OX40) (Adapted from Lee and Kim, 2019).
