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Activation of iCasp9 induces the death of transduced cells. iCasp9 is synthetized in the transduced CAR-T cell as a homodimer. Administration of the chemical inducer of dimerization (CID) AP1903 causes iCasp9 dimerization and thus activation, which in turn triggers a signaling cascade leading to the apoptosis of the CAR-T cells (Adapted from Li and Zhao, 2017).
