Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 16;21(22):8620. doi: 10.3390/ijms21228620

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

CAR T cells with an elimination marker. huEGFRt and CD20 have been tested as elimination marker systems co-delivered with CAR-T cells. The huEGFRt suicide molecule can be activated with an anti-EGFR cetuximab. In contrast, RQR8 (a 136-amino-acid marker with epitopes from CD34 and CD20) has a dual role, by acting simultaneously as a selection marker when CD34 is targeted with an anti-CD34 MAb (QBEnd/10) and as a suicide molecule when CD20 is targeted with rituximab (Adapted from Li and Zhao, 2017).