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. 2020 Nov 16;21(22):8620. doi: 10.3390/ijms21228620

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic representation of switchable adaptors. (1) Tag-specific adaptors CARs: (a) biotin-binding immune receptors (BBIRs), (b) split, universal, and programmable (SUPRA) CARs, (c) α-FITC CARs, (d) UniCARs, (e) α-peptide-neoepitope (α-PNE) CARs, (f) SpyCatcher, (g) fusion protein (FP) CARs, (2) bispecific antibody-binding (BsAb) adaptor CARs: (h) BsAb immune receptors (BsAb-IRs), (i) synthetic agonistic receptors (SARs), (3) Fc-binding CARs: (j) ADCC-mediating immune receptor (Adapted from Arndt et al., 2020).