ADCC |
Antibody-dependent cellular cytotoxicity |
HSV-TK |
Herpes simplex virus thymidine kinase gene |
ALL |
Acute lymphoblastic leukemia |
iCAR |
Inhibitory CAR |
AML |
Acute myelogenous leukemia |
iCasp9 |
Inducible caspase-9 |
ASN |
Asunaprevir |
IFNγ |
Interferon gamma |
BBIR |
Biotin-binding immune receptor |
IgG |
Immunoglobulin G |
BMT |
Bone marrow transplantation |
IL-2 |
Interleukin-2 |
BPDCN |
Blastic plasmacytoid dendritic cell neoplasm |
ITAM |
Immunoreceptor tyrosine-based motif |
BsAb |
Bispecific antibody |
mAb |
Monoclonal antibody |
BsAb-IR |
BsAb immune receptor |
MSLN |
Mesothelin |
CAR-T cell |
Chimeric antigen receptor T cell |
MHC |
Major histocompatibility complex |
CD |
Cluster of differentiation |
NHL |
Non-Hodgkin’s lymphoma |
CID |
Chemical induction of dimerization |
NK |
Natural killer |
CLL |
Chronic lymphoblastic leukemia |
PD-1 |
Programmed cell death-1 |
CNS |
Central nervous system |
PNE |
Peptide neoepitope |
CRS |
Cytokine release syndrome |
PSCA |
Prostate stem cell antigen |
CTLA-4 |
Cytotoxic T-lymphocyte-associated protein 4 |
PSMA |
Prostate-specific membrane antigen |
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rtTA |
Reverse Tet transactivator |
DIPG |
Diffuse intrinsic pontine glioma |
SAR |
Synthetic agonistic receptor |
DLBCL |
Diffuse large B cell lymphoma |
SWIFF-CAR |
Switch-off CAR |
DMG |
Diffuse midline glioma |
SMASh |
Small-molecule-assisted shutoff |
Dox |
Doxycycline |
SUPRA |
Split, universal, and programmable |
ECD |
Extracellular domain |
SynNotch |
Synthetic Notch |
EGFR |
Epidermal growth factor receptor |
TAA |
Tumor-associated antigen |
Fab |
Fragment antigen binding |
TCR |
T cell receptor |
FDA |
Food and Drug Administration |
Tet |
Tetracycline |
FITC |
Fluorescein isothiocyanate |
TKI |
Tyrosine kinase inhibitor |
GBM |
Glioblastoma |
TM |
Transmembrane |
GCV |
Ganciclovir |
TNF-α |
Tumor necrosis factor alfa |
GMP |
Good manufacturing practice |
TRUCK |
T cells redirected for universal cytokine-mediated killing |
GVHD |
Graft-versus-host disease |
TSA |
Tumor-specific antigen |
HER2 |
Human epidermal growth factor receptor-2 |
ZAP70 |
Zeta-chain-associated protein kinase 70 |