Table 5.
Summary of clinical trials using Fc-binding adaptor CARs.
| CAR Adaptor | Adaptor Molecule | Cancer Type | NCT Number |
|---|---|---|---|
| CD16-BB/ζ (ACTR087) |
Rituximab | Refractory or relapsed CD20-positive B cell lymphoma |
NCT02776813 |
| CD16-28 (ACTR707) |
NCT03189836 | ||
| ACTR087 ACTR707 |
Trastuzumab | HER2-positive advanced solid tumor cancers | NCT03680560 |
| ACTR087 ACTR707 |
Rituximab Trastuzumab SEA-BCMA |
B cell lymphoma MM HER2-positive solid tumor cancers |
NCT02840110 |
| ACTR087 | SEA-BCMA | Relapsed or refractory MM | NCT03266692 |