Figure 3.
Cross-species analysis of osteosarcoma drug response reveals sensitivity to proteasome inhibition. (A) A high-throughput screen of 119 oncology compounds across nine osteosarcoma cell lines revealed species-specific clustering by drug response. (B) Although both individual and species-specific responses exist across osteosarcomas, there is a strong correlation between dog and human cell lines (R2 = 0.89). (C) Standard-of-care agents, such as anthracyclines and methotrexate are among the top hits. (D) Cell-line specific responses vary widely to targeted agents and other chemotherapeutics. (E) Proteasome inhibitors carfilzomib and bortezomib demonstrate efficacy across all nine cell lines.