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. 2020 Nov 12;10(11):852. doi: 10.3390/brainsci10110852

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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SARS-CoV-2 distribution in human body. A—Viremia: SARS-SoV-2 virus dissemination throughout the body via the bloodstream. B—Neurotropism via circulation and/or an upper nasal transcribrial route that enables the COVID-19 to modify the function of the blood–brain barrier or directly reach the brain. C—Virus binding and engaging with the ACE2 receptors. D—SARS-CoV-2 docks on the ACE2 via spike protein (blue); major organs–lungs, heart, kidneys, intestines, brain, and testicles, that express ACE2 receptors and are possible targets of COVID-19 (D, golden spikes) [45].