Figure 1.

Treatment algorithm for antiphospholipid syndrome, adapted from [29]. aPL = antiphospholipid antibodies; CV = cardiovascular; DOAC = direct oral anticoagulant; INR = international normalized ratio; LDA = low dose aspirin; LMWH = low molecular weight heparin; VKA = vitamin k antagonist. Recommendation grade: B: consistent level 2 or 3 studies, or extrapolations from level 1 studies; C: level 4 studies or extrapolations from level 2 or 3 studies; D: level 5 evidence or troublingly inconsistent or inconclusive studies of any level. * Surgery, pregnancy/postpartum, and immobilization.