Figure 1.

TLR2 deficiency exacerbates psoriasiform dermatitis induced by imiquimod treatment. Shaved back skin and ears of wild-type (WT) and TLR2 knockout (TLR2 KO) mice were topically treated with imiquimod for 5 consecutive days. (A) Phenotypical manifestation of WT and TLR2 KO mouse back skin induced by imiquimod application at day 5. (B) Disease severity and ear thickness during imiquimod treatment. ** p < 0.01. Clinical scores for disease severity were calculated daily using a scoring system based on the clinical psoriasis area and severity index. Data are presented as mean ± SEM of three independent experiments (n = 9 for each group). * p < 0.05 versus WT mice with imiquimod application.