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. 2020 Nov 13;21(22):8554. doi: 10.3390/ijms21228554

Figure 1.

Figure 1

Scheme of the structure of the NR5A1 protein and localization of studied variations. Critical functional domains comprise a DNA-binding domain (DBD) at the amino terminal (from amino acids 13 to 112) containing two zinc finger domains (ZNI and ZNII) and an A box, the flexible hinge region (amino acids 112–225) and a ligand-binding domain (LBD) (amino acids 225–458) with activation function 1 (AF1) and 2 (AF2). A close-up loop of the first zinc finger domain in DBD is shown where the His24Leu and Cys30Ser alterations are located. Locations of the NR5A1 variations described in this work are indicated by arrow heads.