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. 2020 Nov 13;21(22):8574. doi: 10.3390/ijms21228574

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The results of in silico knockout analysis for place $p_{53}$ (p50–p65 dimer in the nucleus). (A) The simulation of the model without knockout. (B) The impact of knocking out transitions $t_{7}$ (pro IL-18 activation by caspase 1 enzymatic cleavage) and $t_{0}$ (induction cell mediated immunity) (C) The impact of knocking out transitions $t_{0}$ (induction cell mediated immunity) and $t_{1}$ (INF- $γ$ synthesis influencing) (D) The impact of knocking out transitions $t_{20}$ (ICAM1 and VCAM1 up regulation), $t_{23}$ (HD), $t_{61}$ (VCAM1 transcription) and $t_{62}$ (ICAM1 transcription) (E) The impact of knocking out transitions $t_{20}$ (ICAM1 and VCAM1 up regulation), $t_{23}$ (HD), $t_{61}$ (VCAM1 transcription) and $t_{62}$ (ICAM1 transcription) and $t_{0}$ (induction cell-mediated immunity).