Table 4.

The specification of the durations and time intervals assigned to the components of the model. Unfortunately, in the case of the modeled processes (see column ’Process’) only approximate time values can be found in the literature (see columns ’Time Information Coming from the Available Literature’ and ’Time Interval’). Thus, we recalculated those values using the scale of 1 to 1000 (see column ’Duration’) to model the time dependencies between them.

Process	Duration	Time Information Coming from the Available Literature	Time Interval
binding of ligands and proteins, influence of molecules, activation of enzymes, proteins and processes	1	seconds [39]	Very Short
recruitment, connection, phosphorylation, stabilization of molecules, modulation of the activation of proteins and processes, ubiquitination	40	seconds to a minute [40]	Short
decrease in molecules availability, dissociation of protein complexes	100	about twice shorter than synthesis and expression [41]	Medium
synthesis of biomolecules (e.g., INF-$\gamma$, pro IL-18), increase in molecules availability/production, TNFR1 endocytosis, translocation of protein complexes from cytosol to nucleus and from nucleus to cytosol, lipids peroxidation	200	>minutes [40]	Long
severe inflammation, differentiation of monocytes into macrophages	500	>hours [37]	Very Long
atherosclerotic plaque development, CVD	1000	>days [37,41]	Very, Very Long