Table 7.

The 223 minimal t-invariants of the model clustered by UPGMA algorithm. The second and third column of the table give the total number of t-invariants in the cluster, together with its biological interpretation. The last column lists the processes contained in the clusters.

Cluster No.	Biological Interpretation	No. of t-Invariants	Contained Processes
			MCT-Sets	Single Transitions
$c_1$	SODD signaling pathway	1	$m_{11}$
$c_2$	The involvement of the IL-18 cytokine in the formation of the atherosclerotic plaque in patients suffering from CKD without influence of SODD signaling pathway	216	$m_1$, $m_2$, $m_3$, $m_4$, $m_5$, $m_6$, $m_7$, $m_8$, $m_9$, $m_{10}$	$t_1$, $t_2$, $t_5$, $t_6$, $t_8$, $t_{15}$, $t_{16}$, $t_{17}$, $t_{18}$, $t_{20}$, $t_{21}$, $t_{22}$, $t_{23}$, $t_{27}$, $t_{28}$, $t_{34}$, $t_{60}$, $t_{61}$, $t_{62}$, $t_{63}$, $t_{65}$, $t_{66}$
$c_3$	pro IL-18 signaling pathway and activation of macrophages by the classical pathway	1	$m_9$, $m_{10}$	$t_6$, $t_{18}$
$c_4$	IL-18 synthesis and IL-18- mediated INF-$\gamma$ induction	1	$m_9$, $m_{10}$	$t_1$, $t_2$, $t_6$, $t_8$
$c_5$	activation of macrophages by INF-$\gamma$ leading to lipids peroxidation and atherosclerotic plaque development	1	$m_9$	$t_{15}$, $t_{16}$, $t_{27}$, $t_{28}$
$c_6$	influence of NO on cardiovascular system and activation of the innate immune system through TLR together with pro IL-18 signaling pathway leading to atherosclerosis development	3	$m_1$, $m_3$, $m_4$, $m_5$, $m_9$, $m_{10}$	$t_1$, $t_2$, $t_6$, $t_8$, $t_{16}$, $t_{23}$, $t_{27}$, $t_{28}$, $t_{34}$