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Upon stimulation, TRM cells can recirculate into the blood by inducing the expression of higher levels of CD69, CCR7 and S1PR1. In the blood they can have systemic effector functions and convey hepatic immune cell attraction. For the infiltration into the liver, memory T cells express high levels of the hepatic homing markers LFA-1, CD103, CXCR6, CXCR3 and CD69. In the liver they downregulate the expression of these homing receptors and differentiate into liver-resident TRM cells.
