Table 1.
Basic parameters.
| VH (n = 6) | AAT (n = 6) | TAC (n = 6) | TAC + AAT (n = 6) | |
|---|---|---|---|---|
| Baseline BW, g | 254.3 ± 5.0 | 253.0 ± 7.0 | 253.0 ± 5.2 | 256.7 ± 5.5 |
| Last BW, g | 400.3 ± 8.9 | 397.7 ± 14.7 | 364.3 ± 6.4 *** | 358.7 ± 12.8 *** |
| BW gain, g | 146.0 ± 10.8 | 144.7 ± 18.4 | 111.3 ± 7.2 *** | 102.0 ± 14.4 *** |
| Serum BUN, mg/dL | 16.1 ± 1.0 | 15.5 ± 1.4 | 61.1 ± 8.9 *** | 45.0 ± 4.8 ***, ## |
| Serum creatinine, mg/dL | 0.40 ± 0.04 | 0.39 ± 0.03 | 0.67 ± 0.11 *** | 0.53 ± 0.05 ***, ## |
| TAC con, ng/mL | NA | NA | 26.3 ± 4.8 | 25.7 ± 5.1 |
Values are presented as mean ± SD; *** p < 0.001 vs. VH; ## p < 0.01 vs. TAC. Abbreviations: VH, vehicle group, AAT, alpha-1 antitrypsin treatment group; TAC, tacrolimus treatment group; TAC + AAT, tacrolimus and alpha-1 antitrypsin cotreatment group; BW, body weight; BUN, blood urea nitrogen; TAC con, tacrolimus concentration.