Table 3.
Obstruction protocols in previous studies.
| Animal | Target Gland | Obstruction Protocol | Duration | Ref. | |||
|---|---|---|---|---|---|---|---|
| Material | Method | Control | Obstruction | Deobstruction | |||
| Mice | SMG (unilateral) | 6–0 Ethicon suture | Normal | 3, 5, 7 days | − | [99] | |
| SMG (unilateral) | Metal Sugita titanium aneurysm clip | Normal | 7 days | 0, 1, 3, 7, 14 days | [78] | ||
| SMG (unilateral) | Silk thread | Normal | 8 weeks | − | [76] | ||
| SMG (unilateral) | Surgical sutures | Contralateral | 0, 1, 3, 6, 12, 24 h, 1, 3, 6 days | − | [94] | ||
| SMG (unilateral) | Sugita titanium aneurysm clip | Contralateral | 2 months | 1 week, 1, 2 months | [84] | ||
| SMG (unilateral) | Surgical sutures | Contralateral | 7 days | 28 day | [85] | ||
| Rat | PG (bilateral) | 3–0 silk ligature | Sham | 7 days | 7, 30 days | [92] | |
| PG | Suture | Normal | 1, 7, 15, 21, 30, 60 days | − | [100] | ||
| PG (unilateral) | Clip | Sham | 14 days | 2, 8, 14, 21, 25, 28 days | [101] | ||
| PG (unilateral) | Liu et al. 1998 | 2 weeks | 1, 2 weeks | [91] | |||
| PG (unilateral) | Ligaclips, double clipped | Sham | 7 days | 0, 1, 2, 3, 4, 5, 7, 10, 14 days | [79] | ||
| PG (unilateral) | Metal clips, double clipped | Normal | 7 days | 0, 1, 3, 5, 7, 10, 12, 14, 17, 21 days | [102] | ||
| PG (unilateral) | 4–0 silk, double ligated | Normal | 12,18 h/1, 2, 3, 4, 5, 7 days/2,3,4,8,12,24 weeks | − | [82] | ||
| SMG (unilateral) | Surgical sutures | 7 mm distal to the gland hilum | Contralateral | 3 days | 3, 7, 14, 21 days | [93] | |
| SMG (unilateral) | Metal clip | Contralateral | 1 day | 3 days | [24] | ||
| SMG (unilateral) | Metal clip | Contralateral | 4 weeks | 8 weeks | [83] | ||
| SMG (unilateral) | Metal microclip | 5 mm posterior to the ductal orifice | Contralateral | 1 day | − | [75] | |
| SMG+SLG | Metal clip | Normal | 2 weeks | 3 days | [81] | ||
| SMG+SLG | Metal clip | Normal | 2 weeks | 3, 5, 7 days, 8 weeks | [103] | ||
| SMG | 3–0/8–0 silk sutures | Midportion/the orifice of the duct | Normal | 1, 3, 5, 7 days | − | [104] | |
| SMG (unilateral) | − | Normal | 1, 3, 7, 14, 21 days | − | [105] | ||
| SMG (unilateral) | Surgical vascular ligation clip | 5 mm distal to the glandular porta | Contralateral | 1, 3, 7 days | 1, 2 weeks | [106] | |
| SMG | 8–0 suture | Sham | 2, 3, 4 weeks | − | [17] | ||
| SMG (unilateral) | Metal microclip | 5 mm posterior to the ductal orifice | Contralateral | 1, 4, 8 weeks | 8, 16, 24 weeks | [11] | |
| SMG (bilateral) | Metal clip | Near the hilum | Normal | 7 days | 0, 1, 3, 5, 7, 11 days | [80] | |
| SMG (bilateral) | Metal clip | Normal | 7 days | 0,3,7,14 days | [107] | ||
| SMG (unilateral) | Metal clip, double ligation | Normal | 1,2, 3, 4, 5, 7, (10), 14, (21), 28 days | − | [88,96] | ||
| SMG(unilateral) | Metal clip, double ligation | Near the hilum of the gland | Normal | 7 days | 0, 1, 2, 3, 4, 5, 7, 10, 14 days | [108,109] | |
| SMG (unilateral) | Ligaclips, double ligation | Near the hilum of the gland | Normal | 1, 3, 5, 10, 14 days | − | [110,111] | |
| SMG, SLG (bilateral) | − | At a distance of 2 mm from the organs | Sham | 2 weeks | − | [112] | |
| SMG(+SLG) (unilateral) | Metal microclip | less than 5 mm posterior to the ductal orifice/less than 5 mm anterior to the hilum of the gland | Contralateral | 1, 2, 7, 14, 21 days | − | [86] | |
| SMG (+SLG) (unilateral) | Metal microclip | 5 mm posterior to the ductal orifice | Normal | 1, 3, 5, 7, 9, 14 days | − | [113] | |
| SMG, SLG (unilateral) | Metal clips, double ligation | Near the hilum of the gland | Normal | 1, 3, 5, 7, 10, 14, 28 days | − | [114] | |
| SLG (unilateral) | Metal clip, double ligation | Near the hilum of the SLG | Normal | 1, 3, 5, 7, 10, 14, 28 days | [97] | ||
| SLG (unilateral) | Metal clip/ligaclips, double ligation | Near the hilum of the SLG | Normal | 7 days | 0, 1, 2, 3, 4, 5, 7, 10, 14 days | [98,115] | |
| Cat | PG (unilateral) | 3–0 silk sutures | Contralateral | From 1 to 365 days | − | [21] | |
| PG, SMG, SLG (unilateral) | 3/0 braided silk | Contralateral | From 1 to 365 days | − | [116] | ||
| Rabbit | PG (bilateral) | 3–0 silk suture | Sham | 1, 7, 14, 30, 60 days | − | [95] | |
| SMG | 6–0 nylon thread | At 5 mm behind the orifice of the duct | 2, 4, 8 weeks | − | [117] | ||
PG, parotid gland; SMG, submandibular gland; SLG, sublingual gland; CHART, continuous hyperfractionated accelerated radiotherapy.