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. 2020 Nov 16;12(11):3523. doi: 10.3390/nu12113523

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Mechanisms of action of EETs through three main cellular targets. Verity of EET functions occur through PPAR-, TRP-, and GPCR-dependent mechanism, which activates intercellular pathways that modulate transcription factors in the target cell; (B) The possible anti-inflammatory mechanism of EETs. Abbreviations- ATF6: activating transcription factor 6, EETs: epoxyeicosatrienoic acids, ER: endoplasmic reticulum, GPCR: G protein-coupled receptor, IRE1α: inositol-requiring enzyme alpha, PERK: protein kinase R-like endoplasmic reticulum kinase, PPAR: peroxisome proliferator-activated receptor, TRP: transient receptor potential channel, ROS: reactive oxygen species. Figure is in some parts created with biorender.com.