Table 1.
Ranking of the 50 most highly expressed miRNAs in five healthy sample types. Individual rankings per study are presented in Supplementary Table S1. MiRNAs in bold are abundant in all interrogated sample types. In Supplementary Table S7, the unique physiological roles and pathway involvement for the 7 shared miRNAs (bold) are shown.
| Ranking | Breast Tissue [22,23,24,25] |
Nipple Aspirate Fluid (This Study) |
Breast Milk [26,27,28,29,30,31,32,33,34,35] |
Plasma [27,36] |
Serum ([37,38] and This Study) |
|---|---|---|---|---|---|
| 1 | hsa-miR-24-3p | hsa-miR-205-5p | hsa-miR-148a-3p | hsa-miR-451a | hsa-miR-451a |
| 2 | hsa-miR-21-5p | hsa-miR-203a-3p | hsa-miR-22-3p | hsa-miR-92a-3p | hsa-miR-92a-3p |
| 3 | hsa-miR-23a-3p | hsa-miR-26b-5p | hsa-miR-146b-5p | hsa-miR-21-5p | hsa-miR-26a-5p |
| 4 | hsa-let-7f-5p | hsa-miR-221-3p | hsa-miR-30d-5p | hsa-miR-126-3p | hsa-miR-22-3p |
| 5 | hsa-let-7b-5p | hsa-let-7b-5p | hsa-miR-30a-5p | hsa-miR-320a-3p | hsa-miR-25-3p |
| 6 | hsa-miR-22-3p | hsa-miR-27a-3p | hsa-miR-26a-5p | hsa-miR-122-5p | hsa-miR-423-5p |
| 7 | hsa-let-7a-5p | hsa-miR-451a | hsa-miR-375-3p | hsa-let-7b-5p | hsa-miR-21-5p |
| 8 | hsa-miR-30a-5p | hsa-miR-92a-3p | hsa-let-7a-5p | hsa-miR-191-5p | hsa-miR-16-5p |
| 9 | hsa-miR-125b-5p | hsa-miR-16-5p | hsa-miR-200a-3p | hsa-miR-223-3p | hsa-miR-148a-3p |
| 10 | hsa-let-7g-5p | hsa-let-7g-5p | hsa-miR-141-3p | hsa-miR-24-3p | hsa-let-7a-5p |
| 11 | hsa-miR-143-3p | hsa-miR-24-3p | hsa-miR-21-5p | hsa-miR-16-5p | hsa-let-7f-5p |
| 12 | hsa-miR-451a | hsa-miR-200c-3p | hsa-let-7f-5p | hsa-miR-19b-3p | hsa-miR-27a-3p |
| 13 | hsa-miR-99a-5p | hsa-miR-200b-3p | hsa-miR-181a-5p | hsa-miR-486-5p | hsa-miR-122-5p |
| 14 | hsa-miR-320a-3p | hsa-miR-99a-5p | hsa-miR-30b-5p | hsa-miR-150-5p | hsa-let-7b-5p |
| 15 | hsa-miR-145-5p | hsa-miR-21-5p | hsa-let-7b-5p | hsa-miR-17-5p | hsa-miR-142-5p |
| 16 | hsa-miR-205-5p | hsa-miR-92b-3p | hsa-let-7g-5p | hsa-miR-484 | hsa-miR-30d-5p |
| 17 | hsa-miR-126-3p | hsa-miR-15a-5p | hsa-miR-92a-3p | hsa-miR-106a-5p | hsa-miR-181a-5p |
| 18 | hsa-miR-26a-5p | hsa-miR-193b-3p | hsa-miR-191-5p | hsa-miR-20a-5p | hsa-miR-126-3p |
| 19 | hsa-miR-19b-3p | hsa-miR-30b-5p | hsa-miR-320a-3p | hsa-miR-146a-5p | hsa-miR-191-5p |
| 20 | hsa-let-7i-5p | hsa-miR-29a-3p | hsa-miR-182-5p | hsa-miR-26a-5p | hsa-let-7i-5p |
| 21 | hsa-let-7c-5p | hsa-miR-34a-5p | hsa-miR-423-5p | hsa-miR-25-3p | hsa-miR-101-3p |
| 22 | hsa-miR-148a-3p | hsa-miR-26a-5p | hsa-miR-99b-5p | hsa-miR-222-3p | hsa-miR-24-3p |
| 23 | hsa-miR-199a-3p | hsa-miR-125b-5p | hsa-miR-200c-3p | hsa-miR-342-3p | hsa-let-7g-5p |
| 24 | hsa-miR-101-3p | hsa-miR-22-3p | hsa-let-7i-5p | hsa-miR-30a-5p | hsa-miR-26b-5p |
| 25 | hsa-miR-100-5p | hsa-miR-365a-3p | hsa-miR-200b-3p | hsa-miR-126-5p | hsa-miR-146a-5p |
| 26 | hsa-miR-29a-3p | hsa-miR-148a-3p | hsa-miR-101-3p | hsa-miR-30c-5p | hsa-miR-486-5p |
| 27 | hsa-miR-103a-3p | hsa-miR-17-5p | hsa-miR-24-3p | hsa-miR-142-3p | hsa-miR-223-3p |
| 28 | hsa-let-7d-5p | hsa-miR-20a-5p | hsa-miR-27b-3p | hsa-miR-30d-5p | hsa-miR-144-3p |
| 29 | hsa-miR-125a-5p | hsa-miR-652-3p | hsa-miR-29a-3p | hsa-miR-30e-5p | hsa-miR-143-3p |
| 30 | hsa-miR-141-3p | hsa-miR-144-3p | hsa-miR-99a-5p | hsa-miR-30b-5p | hsa-miR-30e-5p |
| 31 | hsa-miR-199b-3p | hsa-miR-125a-5p | hsa-miR-429 | hsa-miR-192-5p | hsa-miR-320a-3p |
| 32 | hsa-miR-199a-5p | hsa-miR-210-3p | hsa-miR-16-5p | hsa-miR-425-5p | hsa-miR-103a-3p |
| 33 | hsa-miR-181a-5p | hsa-miR-25-3p | hsa-miR-378a-3p | hsa-miR-423-5p | hsa-miR-10b-5p |
| 34 | hsa-miR-30b-5p | hsa-miR-361-5p | hsa-miR-103a-3p | hsa-let-7e-5p | hsa-miR-423-3p |
| 35 | hsa-miR-497-5p | hsa-miR-29b-3p | hsa-miR-186-5p | hsa-miR-106b-5p | hsa-miR-126-5p |
| 36 | hsa-miR-30e-5p | hsa-miR-195-5p | hsa-miR-151a-3p | hsa-miR-148a-3p | hsa-miR-27b-3p |
| 37 | hsa-miR-140-3p | hsa-miR-181b-5p | hsa-miR-10a-5p | hsa-miR-19a-3p | hsa-miR-16-2-3p |
| 38 | hsa-miR-27a-3p | hsa-miR-30c-5p | hsa-miR-25-3p | hsa-let-7i-5p | hsa-miR-150-5p |
| 39 | hsa-miR-130a-3p | hsa-miR-342-3p | hsa-miR-30e-5p | hsa-miR-378a-3p | hsa-miR-92b-3p |
| 40 | hsa-miR-191-5p | hsa-miR-181a-5p | hsa-miR-181b-5p | hsa-miR-22-3p | hsa-miR-484 |
| 41 | hsa-miR-195-5p | hsa-miR-223-3p | hsa-miR-125a-5p | hsa-miR-146b-5p | hsa-let-7d-5p |
| 42 | hsa-miR-939-5p | hsa-miR-146a-5p | hsa-miR-30c-5p | hsa-miR-151a-3p | hsa-miR-151a-3p |
| 43 | hsa-let-7e-5p | hsa-miR-324-5p | hsa-miR-193b-3p | hsa-miR-195-5p | hsa-miR-185-5p |
| 44 | hsa-miR-221-3p | hsa-miR-150-5p | hsa-miR-335-5p | hsa-miR-185-5p | hsa-miR-23a-3p |
| 45 | hsa-miR-26b-5p | hsa-miR-145-5p | hsa-miR-27a-3p | hsa-miR-143-3p | hsa-miR-107 |
| 46 | hsa-miR-10b-5p | hsa-miR-103a-2-5p | hsa-miR-19b-3p | hsa-miR-186-5p | hsa-miR-199a-3p |
| 47 | hsa-miR-143-5p | hsa-miR-193a-3p | hsa-miR-148a-5p | hsa-miR-93-5p | hsa-miR-148b-3p |
| 48 | hsa-miR-628-3p | hsa-miR-484 | hsa-miR-146a-5p | hsa-miR-140-3p | hsa-miR-140-3p |
| 49 | hsa-miR-423-5p | hsa-miR-130a-3p | hsa-miR-29c-3p | hsa-miR-375-3p | hsa-miR-17-5p |
| 50 | hsa-miR-519d-3p | hsa-miR-19a-3p | hsa-let-7e-5p | hsa-let-7g-5p | hsa-miR-19b-3p |