Figure 10.

Genetic deletion of TRPV1 reduced NaHS-evoked extracellular Ca²⁺ influx in mCRC cells. (A), the increase in [Ca²⁺]_i evoked by capsaicin (10 µM) in mCRC cells transfected with a scrambled construct (Ctrl) was remarkably reduced in mCRC cells transfected with a selective siTRPV1. (B), mean ± SE of the percentage of the Ca²⁺ response to capsaicin under the designated treatments. (C), the increase in [Ca²⁺]_i evoked by NaHS (100 µM) in mCRC cells transfected with a scrambled construct (Ctrl) was remarkably reduced in mCRC cells transfected with a selective siTRPV1. (D), mean ± SE of the percentage of the Ca²⁺ response to NaHS under the designated treatments. Student’s t-test has been used for statistical comparison. In Panel B and D: *** p ≤ 0.001.