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. 2020 Nov 14;21(22):8599. doi: 10.3390/ijms21228599

Figure 1.

Figure 1

PD-MSCs increased the invasion ability of trophoblasts via activation of MMPs and the Rho family signaling pathway. (A) Invasive trophoblasts with and without PD-MSC cocultivation were assessed by invasion assays (magnification, 100× g). (B) Trophoblasts were quantified by Image J. The mRNA expression of (C) HIF1a, (D) MMP-2, (E) MMP-9, (F) FAK, (G) Rho A, (H) ROCK1 and (I) Rac1 in invasive trophoblast cells with and without PD-MSC cocultivation over time. The data was performed at least in triplicate and expressed as the means ± S.D. Indicates * p < 0.05. White bar: control, Black bar: PD-MSC cocultivation. *: control vs. PD-MSC cocultivation at each time point. PD-MSCs: Placenta-derived mesenchymal stem cells; MMP: Matrix metalloproteinase; mRNA: messenger RNA; HIF1a: Hypoxia-inducible factor 1a; FAK: Focal adhesion kinase; ROCK1: Rho-associated coiled-coil-containing protein kinase 1; Rac1: Ras-related C3 botulinum toxin substrate 1.