Figure 2.

Comparison of the liver lipidome in murine and human NAFLD. (A) Wildtype mice were fed standard diet or ALiOS diet for 24 weeks. Liver lipidome was characterized by gas chromatography (GC) as described. Composition of the lipidome is depicted in categories of saturated, monounsaturated, diunsaturated and polyunsaturated fatty acids. (B) Fatty acid composition of mouse and human livers without steatosis (white bars) and with steatosis (black bars) was determined. Previously described fatty acid ratios associated with NAFLD are depicted (mean ± standard deviation; n = 5 for mouse, n = 9–10 for human liver tissue; * p < 0.05; t-test).